Despair is the complete loss or absence of hope.
In psychology, despair refers to a profound sense of hopelessness and helplessness.
Common expressions with "despair":
1. "In despair" - feeling completely hopeless
2. "Drive sb to despair" - make someone feel extremely upset
3. "A cry of despair" - an expression of complete hopelessness
Despair这词儿说白了就是"绝望"的意思，指那种彻底没指望了的感觉。
在心理学里头，despair说的是一种特别强烈的无助感和绝望感，整个人都蔫儿了那种。
常见搭配用法：
1. "In despair" - 就是"绝望中"的意思，比如：He was in despair after losing his job.（失业后他整个人都绝望了）
2. "Drive sb to despair" - 把某人逼疯/逼急眼了，比如：Her constant nagging drove him to despair.（她整天叨叨叨把他烦得要死）
3. "A cry of despair" - 绝望的呐喊，比如：The refugees' cries of despair could be heard everywhere.（难民的绝望呼喊声随处可闻）
补充说明：despair和depression（抑郁）不太一样，前者更强调"彻底放弃希望"的感觉，后者更多指长期的情绪低落。咱中国人说的"心灰意冷"、"万念俱灰"这些词儿都能对应上。